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In the WHI estrogen-alone substudy, after an average follow-up of 7. The number of doses per tube will vary with dosage requirements and patient handling. Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. In postmenopausal women, a significant proportion of the circulating estrogens exist as sulfate conjugates, especially estrone sulfate, which serves as a circulating reservoir for the formation of more active estrogens. For women with a history of cholestatic jaundice associated with past estrogen use or with pregnancy, caution should be exercised and in the case of recurrence, medication should be discontinued.

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