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With the advent of HER2-targeted therapies, progressive visceral disease is significantly diminished. It is clear that if the current guidelines were applied, these patients would be denied biological therapy from which they could benefit. Copy and paste a formatted citation. Appl Immunohistochem Mol Morphol. The value of histological grade in breast cancer: As reported in previous studies, the presence of certain biopathological factors such as peritumoral vascular invasion, high histological grade and high proliferative index, appears to play a fundamental role in the identification of these cases 20 ,

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